An experimental study was conducted to evaluate the mechanism of toxicity due to maduramicin in broilers. The broiler chicks were fed on the diet containing 8 ppm of maduramicin for 6 weeks. The immune status, concentration of glutathione and the activities of antioxidant defense enzymes such as glutathione peroxidase (GSH-Px), glutathione reductase (GSH-R) and catalase were assessed at every 2 weeks interval. The study revealed significant (P< 0.05) increase in the activity of the antioxidant enzymes and a significant (P< 0.05) reduction in the glutathione and HI titre of the birds fed on maduramicin. From this study, it is concluded that the toxicity of maduramicin is due to induction of oxidative stress and immunosuppression.
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